Furthermore, about 20% of cases of severe acute pancreatitis are necrotizing disease, which accounts for nearly all the morbidity and death associated with acute pancreatitis. Some 20% to 30% of patients develop severe disease manifested by pancreatic necrosis, abscess or pseudocysts, and extrapancreatic complications such as vital organ dysfunction. In Germany, the incidence of this disease is rising and has now reached 23 cases per 100,000 persons per year. An estimated 210,000 new cases of acute pancreatitis occur each year in the United States. Severe acute pancreatitis is characteristic of a serious pathogenetic condition with high incidence of complications and 20%–30% of mortality, and there is still no breakthrough in treatment. Acute pancreatitis is a mild, self-limited disease and is a common cause of acute abdominal pain. There are two types of pancreatitis, namely, the chronic and acute types chronic pancreatitis is a clinical challenge, with persistent or recurrent abdominal pain as the most compelling symptom that drives patients to seek medical care. Abdominal pain is a major clinical challenge in pancreatitis, present in up to 90% of the patients, and is the primary cause of hospitalization. Pancreatitis is an inflammatory disorder that causes irreversible anatomical changes and damage, including infiltration of inflammatory cells, fibrosis, and calcification of the pancreas with destruction of the glandular structure, and thereby affects normal digestion and absorption of nutrients. The present meta-analysis indicated that serum HMGB1 level was statistically elevated in patients with pancreatitis, and thus serum levels of HMGB1 could be determined to be a useful biomarker for pancreatitis patients.
In the subgroup analysis by country, high serum level of HMGB1 may be related to pancreatitis progression in China, Korea, Hungary, and Japan populations (all P < 0.05). The meta-analysis results showed a positive association between serum HMGB1 levels and the progression of pancreatitis. We performed a final analysis of 841 subjects from 12 clinical case-control studies.
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Version 12.0 STATA software was used for statistical analysis. Studies were pooled and standard mean difference (SMD) and its corresponding 95% confidence intervals (95% CIs) were calculated. We conducted a meta-analysis by searching in the PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases without any language restrictions. This meta-analysis focused on the clinical significance of serum HMGB1 levels in pancreatitis patients, with the goal of building a novel diagnostic score model. Aberrant expression of high mobility group box-1 protein (HMGB1) contributes to the progression of various inflammatory diseases. Box lunches are another option for off-campus field trips during your camp or conference.įor additional information or assistance scheduling your event, please contact the Director of Camps and Conferences, at 62, 1-80 ext.Background. Our dining services can provide youth fare, formal dinners, and anything in between. We have facilities for small groups to several hundred, with housing options as well. Our campus is wireless, so you can continue to keep up with the outside world if you want to! Enjoy the local hospitality while you're in the area and check out Winfield's downtown, a place you can still casually stroll and do some window shopping! Southwestern is a beautiful campus situated on the top of a hill overlooking the Walnut Valley in Winfield, Kansas. Camps and Conferences Welcome to the Office of Camps and Conferences!Īre you considering attending a camp or conference to be held at Southwestern? Here you will find information about the camps and conferences held on Southwestern's campus: online registrations, schedules, and links will provide you with the information you need.
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